Progesteron 5a-reduktaza
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| Progesteron 5a-reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.30 | ||||||||
| CAS broj | 72412-84-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Progesteron 5a-reduktaza (EC 1.3.1.30, steroidna 5-alfa-reduktaza, Delta4-steroidna 5alfa-reduktaza (progesteron)) je enzim sa sistematskim imenom 5alfa-pregnan-3,20-dion:NADP+ 5-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5alfa-pregnan-3,20-dion + NADP+ progesteron + NADPH + H+
Testosteron i 20 alfa-hidroksi-4-pregn-3-on mogu da deluju umesto progesterona.
Reference[uredi | uredi kod]
- ↑ Cheng, Y.-J. and Karavolas, H.J. (1975). „Subcellular distribution and properties of progesterone (Δ4-steroid) 5α-reductase in rat medial basal hypothalamus”. J. Biol. Chem. 250: 7997-8003. PMID 240847.
- ↑ Cheng, Y.-J. and Karavolas, H.J. (1975). „Properties and subcellular distribution of Δ4-steroid (progesterone) 5α-reductase in rat anterior pituitary”. Steroids 26: 57-71. PMID 1166484.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.