Polinukleotid adenililtransferaza

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Polinukleotid adenililtransferaza
EC broj
CAS broj 9026-30-6
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Polinukleotid adenililtransferaza (EC, NTP polimeraza, RNK adenilatirajući enzim, AMP polinukleotidileksotransferaza, ATP-polinukleotid adenililtransferaza, ATP:polinukleotidileksotransferaza, poli(A) polimeraza, poli(A) sintetaza, poliadenilatna nukleotidiltransferaza, poliadenilatna polimeraza, poliadenilatna sintetaza, poliadenilno kiselinska polimeraza, poliadenilna polimeraza, terminalna riboadenilatna transferaza, poli(A) hidrolaza, RNK formirajući faktori, PF1, adenozin trifosfat:ribonukleinska kiselina adenililtransferaza) je enzim sa sistematskim imenom ATP:polinukleotid adenililtransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + RNKn \rightleftharpoons difosfat + RNKn+1

Ovaj enzim takođe u izvesnoj meri deluje sa CTP.

Reference[uredi - уреди | uredi izvor]

  1. August, J.T., Ortiz, P.J. and Hurwitz, J. (1962). "Ribonucleic acid-dependent ribonucleotide incorporation. I. Purification and properties of the enzyme". J. Biol. Chem. 237: 3786–3793. PMID 13965521. 
  2. Edmonds, M. and Abrams, R. (1960). "Polynucleotide biosynthesis: formation of a sequence of adenylate units from adenosine triphosphate by an enzyme from thymus nuclei". J. Biol. Chem. 235: 1142–1149. PMID 13819354. 
  3. Gottesman, M.E. and Canellakis, E.S. (1966). "The terminal nucleotidyltransferases of calf thymus nuclei". J. Biol. Chem. 241: 4339–4352. PMID 4288534. 
  4. Krakow, J.S., Coutsogeorgopoulos, C. and Canellakis, E.S. (1962). "Studies on the incorporation of deoxyribonucleic acid". Biochim. Biophys. Acta 55: 639–650. PMID 14459258. 
  5. Mans, R.J. and Walter, T.J. (1971). "Transfer RNA-primed oligoadenylate synthesis in maize seedlings. II. Primer, substrate and metal specificities and size of product". Biochim. Biophys. Acta 247: 113–121. PMID 4946277. 
  6. Sheldon, R., Jurale, C. and Kates, J. (1972). "Detection of polyadenylic acid sequences in viral and eukaryotic RNA(poly(U)-cellulose columns-poly(U) filters-fiberglass-HeLa cells-bacteriophage T4)". Proc. Natl. Acad. Sci. USA 69: 417–421. PMID 4501121. 

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