Poli (b-D-manuronat) lijaza
| Poli (b-D-manuronat) lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 4.2.2.3 | ||||||||
| CAS broj | 9024-15-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Poli (b-D-manuronat) lijaza (EC 4.2.2.3, alginatna lijaza I, alginatna lijaza, alginaza I, alginaza II, alginaza, poli(beta-D-1,4-manuronid) lijaza, aly (gen)) je enzim sa sistematskim imenom poli((1->4)-beta-D-manuronid) lijaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Eliminativno razlaganje polisaharida koji sadrže beta-D-manuronatne ostatke čime se formiraju oligosaharidi sa 4-dezoksi-alfa-L-eritro-heks-4-enopiranuronozil grupama na njihovim neredukujućim krajevima
Enzim iz bakterija Sphingomonas vrste A1 razlaže alginat.
- ↑ Davidson, I.W., Lawson, C.J. and Sutherland, I.W. (1977). „An alginate lysate from Azotobacter vinelandii phage”. J. Gen. Microbiol. 98: 223-229. PMID 13144.
- ↑ Nakada, H.I. and Sweeny, P.C. (1967). „Alginic acid degradation by eliminases from abalone hepatopancreas”. J. Biol. Chem. 242: 845-851. PMID 6020438.
- ↑ Preiss, J. and Ashwell, G. (1962). „Alginic acid metabolism in bacteria. I. Enzymatic formation of unsaturated oligosaccharides and 4-deoxy-L-erythro-5-hexoseulose uronic acid”. J. Biol. Chem. 237: 309-316. PMID 14488584.
- ↑ Hashimoto, W., Miyake, O., Momma, K., Kawai, S. and Murata, K. (2000). „Molecular identification of oligoalginate lyase of Sphingomonas sp. strain A1 as one of the enzymes required for complete depolymerization of alginate”. J. Bacteriol. 182: 4572-4577. PMID 10913091.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.