Peptidaza mitohondrijalna prerade
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| Peptidaza mitohondrijalna prerade | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.64 | ||||||||
| CAS broj | 86280-61-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Peptidaza mitohondrijalna prerade (EC 3.4.24.64, proteinaza transofmacije mitohondrijskog proteinskog prekursora, matriks peptidaza, matriks procesujuća peptidaza, matriks procesujuća proteinaza, proteinaza transformacije mitohondrijskog proteinskog prekursora, MPP) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Oslobađanje N-terminalnog ciljnih peptida sa prekursornih proteina unesenih u mitohondrion, tipično sa Arg u poziciji P2
Ovaj enzim je prisutan u mitohondrijskom matriksu gljiva i sisara.
Reference[uredi | uredi kod]
- ↑ Jensen, R.E. and Yaffe, M.P. (1988). „Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit”. EMBO J. 7: 3863-3871. PMID 3061808.
- ↑ Witte, C., Jensen, R.E., Yaffe, M.P. and Schatz, G. (1988). „MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease”. EMBO J. 7: 1439-1447. PMID 3044780.
- ↑ Rawlings, N.D. and Barrett, A.J. (1991). „Homologues of insulinase, a new superfamily of metalloendopeptidases”. Biochem. J. 275: 389-391. PMID 2025223.
- ↑ Kalousek, F., Neupert, W., Omura, T., Schatz, G. and Schmitz, U.K. (1993). „Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins”. Trends Biochem. Sci. 18: 249-249. PMID 8212133.
- ↑ Brunner, M. and Neupert, W. (1994). „Purification and characterization of the mitochondrial processing peptidase of Neurospora crassa”. Methods Enzymol. 248: 717-728.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.