Peptidaza C-terminalne obrade
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| Peptidaza C-terminalne obrade | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.102 | ||||||||
| CAS broj | 92480-11-0&title= 216484-75-2, 92480-11-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Peptidaza C-terminalne obrade (EC 3.4.21.102, CtpA genski produkt (Synechocystis sp.), fotosistem II D1 protein obrade peptidaze, proteaza Re, proteaza specifična za rep, Tsp proteaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Enzim specifično prepoznaje C-terminalni tripeptid, Xaa-Yaa-Zaa, u kome je Xaa preferentno Ala ili Leu, Yaa je preferentno Ala ili Tyr, i Zaa je preferentno Ala
Proteolitička obrada D1 proteina fotosistema II je neophodna da bi se omogućila svetlom rukovođeno formiranje tetranuklearnog manganskig klustera, koji je odgovoran za fotosintetičku oksidaciju vode.
Reference[uredi | uredi kod]
- ↑ Keiler, K.C. and Sauer, R.T. (1998). „Tsp protease”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. str. 460-461.
- ↑ Beebe, K.D., Shin, J.N., Peng, J., Chaudhury, C., Khera, J. and Pei, D.H. (2000). „Substrate recognition through a PDZ domain in tail-specific protease”. Biochemistry 39: 3149-3155. PMID 10715137.
- ↑ Liao, D.I., Qian, J., Chisholm, D.A., Jordan, D.B. and Diner, B.A. (2000). „Crystal structures of the photosystem II D1 C-terminal processing protease”. Nat. Struct. Biol. 7: 749-753. PMID 10966643.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Keiler, K.C. and Sauer, R.T. (1998). „Tsp protease”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. str. 460-461.