Peptid-O-fukoziltransferaza
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| Peptid-O-fukoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.221 | ||||||||
| CAS broj | 2605491 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Peptid-O-fukoziltransferaza (EC 2.4.1.221, GDP-L-fukoza:polipeptid fukoziltransferaza, GDP-fukozno proteinska O-fukoziltransferaza, GDP-fukoza:polipeptid fukoziltransferaza) je enzim sa sistematskim imenom GDP-beta-L-fukoza:polipeptid O-alfa-L-fukoziltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- prenosi alfa-L-fukozilni ostatak sa GDP-beta-L-fukoze na serinsku hidroksi grupu proteinskog akceptora
Ovaj enzim učestvuje u biosintezi O-fukozilisanog epidermnog faktora rasta (EGF) i trombospondina tipa 1.
Reference[uredi | uredi kod]
- ↑ Wang, Y. and Spellman, M.W. (1998). „Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells”. J. Biol. Chem. 273: 8112-8118. PMID 9525914.
- ↑ Wang, Y., Shao, L., Shi, S., Harris, R.J., Spellman, M.W., Stanley, P. and Haltiwanger, R.S. (2001). „Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase”. J. Biol. Chem. 276: 40338-40345. PMID 11524432.
- ↑ Wang, Y., Lee, G.F., Kelley, R.F. and Spellman, M.W. (1996). „Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains”. Glycobiology 6: 837-842. PMID 9023546.
- ↑ Hofsteenge, J., Huwiler, K.G., Macek, B., Hess, D., Lawler, J., Mosher, D.F. and Peter-Katalinic, J. (2001). „C-mannosylation and O-fucosylation of the thrombospondin type 1 module”. J. Biol. Chem. 276: 6485-6498. PMID 11067851.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.