Pentalenenska sintaza

Izvor: Wikipedia
Pentalenenska sintaza
Identifikatori
EC broj 4.2.3.7
CAS broj 90597-46-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Pentalenenska sintaza (EC 4.2.3.7, pentalenenska sintetaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (ciklizacija, formira pentalenen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(2E,6E)-farnezil difosfat \rightleftharpoons pentalenen + difosfat

Ovaj enzim je prisutan u Streptomyces avermitilis.

Reference[uredi - уреди]

  1. Cane, D.E. (1983). "Cell-free studies of monoterpene and sesquiterpene biosynthesis". Biochem. Soc. Trans. 11: 510–515. PMID 6642060. 
  2. Cane, D.E. and Tillman, A.M. (1983). "Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate". J. Am. Chem. Soc. 105: 122–124. 
  3. Cane, D.E., Sohng, J.K., Lamberson, C.R., Rudnicki, S.M., Wu, Z., Lloyd, M.D., Oliver, J.S. and Hubbard, B.R. (1994). "Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319". Biochemistry 33: 5846–5857. PMID 8180213. 
  4. Cane, D.E., Abell, C., Harrison, P.H., Hubbard, B.R., Kane, C.T., Lattman, R., Oliver, J.S. and Weiner, S.W. (1991). "Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions". Philos. Trans. R. Soc. Lond. B Biol. Sci. 332: 123–129. PMID 1678531. 
  5. Lesburg, C.A., Zhai, G., Cane, D.E. and Christianson, D.W. (1997). "Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology". Science 277: 1820–1824. PMID 9295272. 
  6. Zu, L., Xu, M., Lodewyk, M.W., Cane, D.E., Peters, R.J. and Tantillo, D.J. (2012). "Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry". J. Am. Chem. Soc. 134: 11369–11371. PMID 22738258. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]