Glicilna endopeptidaza
(Preusmjereno sa stranice PPIV)
| Glicilna endopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.25 | ||||||||
| CAS broj | 149719-24-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glicilna endopeptidaza (EC 3.4.22.25, papajina peptidaza B, papajina proteinaza IV, glicin-specifična proteinaza, papajina proteinaza 4, PPIV, himopapain M) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Preferentno razlaganje: Gly-, u proteinima i malim molekulskim supstratima
Ovaj enzim je izolovan iz papaje, Carica papaya.
- ↑ Polgár, L. (1981). „Isolation of highly active papaya peptidases A and B from commercial chymopapain”. Biochim. Biophys. Acta 658: 262-269. PMID 7018581.
- ↑ Buttle, D.J., Kembhavi, A.A., Sharp, S.L., Shute, R.E., Rich, D.H. and Barrett, A.J. (1989). „Affinity purification of the novel cysteine proteinase papaya proteinase IV and papain from papaya latex”. Biochem. J. 261: 469-476. PMID 2505761.
- ↑ Ritonja, A., Buttle, D.J., Rawlings, N.D., Turk, V. and Barrett, A.J. (1989). „Papaya proteinase IV amino acid sequence”. FEBS Lett. 258: 109-112. PMID 2591528.
- ↑ Buttle, D.J., Ritonja, A., Pearl, L.H., Turk, V. and Barrett, A.J. (1990). „Selective cleavage of glycyl bonds by papaya proteinase IV”. FEBS Lett. 260: 195-197. PMID 2404797.
- ↑ Buttle, D.J., Ritonja, A., Dando, P.M., Abrahamson, M., Shaw, E.N., Wikstrom, P., Turk, V. and Barrett, A.J. (1990). „Interaction of papaya proteinase IV with inhibitors”. FEBS Lett. 262: 58-60. PMID 1690669.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.