P300-CBP koaktivatorska familija
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| E1A vezujući protein p300 | |
|---|---|
| |
| Kristalografska struktura histonskog acetiltransferaznog domena EP300 (N-terminus = plavo, C-terminus = crveno) u kompleksu sa inhibitorom lizin-KoA (ugljenik = belo, kiseonik = crveno, azot = plavo, fosfor = naranđasto).[1] | |
| Identifikatori | |
| Simbol | EP300 |
| Alt. simboli | p300 |
| Entrez | 2033 |
| Hugo | 3373 |
| OMIM | 602700 |
| PDB | 3biy |
| RefSek | NM_001429 |
| UniProt | Q09472 |
| Drugi podaci | |
| EC broj | 2.3.1.48 |
| Lokus | Hrom. 22 q13.2 |
| CREB vezujući protein (CBP) | |
|---|---|
| Identifikatori | |
| Simbol | CREBBP |
| Alt. simboli | CBP, RSTS |
| Entrez | 1387 |
| Hugo | 2348 |
| OMIM | 600140 |
| PDB | 3dwy |
| RefSek | NM_004380 |
| UniProt | Q92793 |
| Drugi podaci | |
| EC broj | 2.3.1.48 |
| Lokus | Hrom. 16 p13.3 |
p300-CBP koaktivatorska familija se sastoji od dva blisko srodna transkripciona koaktivirajuća proteina (ili koaktivatora):
- p300 (EP300 ili E1A vezujući protein p300)
- CBP (CREB-vezujući protein ili CREBBP)
Proteini p300 i CBP formiraju interakcije sa brojnim transkripcionim faktorima i deluju tako što povišavaju izražavanje njihovih ciljnih gena.[2][3]
Reference[uredi | uredi kod]
- ↑ PDB 3BIY; Liu X, Wang L, Zhao K, Thompson PR, Hwang Y, Marmorstein R, Cole PA (February 2008). „The structural basis of protein acetylation by the p300/CBP transcriptional coactivator”. Nature 451 (7180): 846–50. Bibcode 2008Natur.451..846L. DOI:10.1038/nature06546. PMID 18273021.
- ↑ Kasper LH, Fukuyama T, Biesen MA, Boussouar F, Tong C, de Pauw A, Murray PJ, van Deursen JM, Brindle PK (2006). „Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development”. Mol. Cell. Biol. 26 (3): 789–809. DOI:10.1128/MCB.26.3.789-809.2006. PMID 16428436.
- ↑ Vo N, Goodman RH (2001). „CREB-binding protein and p300 in transcriptional regulation”. J. Biol. Chem. 276 (17): 13505–8. DOI:10.1074/jbc.R000025200. PMID 11279224.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.