Oligopeptidaza A
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| Oligopeptidaza A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.70 | ||||||||
| CAS broj | 394250-11-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Oligopeptidaza A (EC 3.4.24.70, 68000-M signalnopeptidna hidrolaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza oligopeptida sa širokom specifičnošću. Gly i Ala se često javljaju na P1 ili P1' ostacima, mada su udaljeniji ostaci takođe važni, npr. Dolazi do razlaganja Z-Gly-Pro-Gly-Gly-Pro-Ala, dok se Z-(Gly)5 ne razlaže
Ovaj enzim je prisutan u bakterijama Escherichia coli i Salmonella typhimurium.
Reference[uredi | uredi kod]
- ↑ Novak, P. and Dev, I.K. (1988). „Degradation of a signal peptide by protease IV and oligopeptidase A”. J. Bacteriol. 170: 5067-5075. PMID 3053642.
- ↑ Conlin, C.A., Vimr, E.R. and Miller, C.G. (1992). „Oligopeptidase A is required for normal phage P22 development”. J. Bacteriol. 174: 5869-5880. PMID 1522065.
- ↑ Conlin, C.A., Trun, N.J., Silhavy, T.J. and Miller, C.G. (1992). „Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene”. J. Bacteriol. 174: 5881-5887. PMID 1325967.
- ↑ Conlin, C.A. and Miller, C.G. (1995). „Oligopeptidase A and peptidyl-dipeptidase of Escherichia and Salmonella”. Methods Enzymol. 248: 567-579. PMID 7674945.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.