O-fosfoseril-tRNKSec kinaza
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| O-fosfoseril-tRNKSec kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.164 | ||||||||
| CAS broj | 91273-83-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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O-fosfoseril-tRNKSec kinaza (EC 2.7.1.164, PSTK, fosfoseril-tRNK(Ser)Sec kinaza, fosfoseril-tRNKSec kinaza) je enzim sa sistematskim imenom ATP:L-seril-tRNKSec O-fosfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Kod arheja i eukarija formiranje selenocisteina se ostvaruje u dva stupnja: O-fosfoseril-tRNKSec kinaza (PSTK) fosforiliše endogeni L-seril-tRNKSec do O-fosfo-L-seril-tRNKSec, i zatim se taj intermedijer konvertuje do L-selenocisteinil-tRNKSec posredstvom enzima EC 2.9.1.2 (Sep-tRNK:Sec-tRNK sintaza).
Reference[uredi | uredi kod]
- ↑ Carlson, B.A., Xu, X.M., Kryukov, G.V., Rao, M., Berry, M.J., Gladyshev, V.N. and Hatfield, D.L. (2004). „Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase”. Proc. Natl. Acad. Sci. USA 101: 12848-12853. PMID 15317934.
- ↑ Sherrer, R.L., O'Donoghue, P. and Soll, D. (2008). „Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation”. Nucleic Acids Res. 36: 1247-1259. PMID 18174226.
- ↑ Khangulov, S.V., Gladyshev, V.N., Dismukes, G.C. and Stadtman, T.C. (1998). „Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer”. Biochemistry 37: 3518-3528. PMID 9521673.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.