Nitronat monooksigenaza
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| Nitronat monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.12.16 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Nitronat monooksigenaza (EC 1.13.12.16, NMO) je enzim sa sistematskim imenom nitronat:kiseonik 2-oksidoreduktaza (formira nitrit).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- etilnitronat + O2 acetaldehid + nitrit + drugi produkti
Enzimi iz gljiva Neurospora crassa i kvasca Williopsis saturnus var. mrakii sadrže nekovalentno vezani FMN kao kofaktor.
Reference[uredi | uredi kod]
- ↑ Francis, K., Russell, B. and Gadda, G. (2005). „Involvement of a flavosemiquinone in the enzymatic oxidation of nitroalkanes catalyzed by 2-nitropropane dioxygenase”. J. Biol. Chem. 280: 5195-5204. PMID 15582992.
- ↑ Ha, J.Y., Min, J.Y., Lee, S.K., Kim, H.S., Kim do, J., Kim, K.H., Lee, H.H., Kim, H.K., Yoon, H.J. and Suh, S.W. (2006). „Crystal structure of 2-nitropropane dioxygenase complexed with FMN and substrate. Identification of the catalytic base”. J. Biol. Chem. 281: 18660-18667. PMID 16682407.
- ↑ Gadda, G. and Francis, K. (2010). „Nitronate monooxygenase, a model for anionic flavin semiquinone intermediates in oxidative catalysis”. Arch. Biochem. Biophys. 493: 53-61. PMID 19577534.
- ↑ Francis, K. and Gadda, G. (2009). „Kinetic evidence for an anion binding pocket in the active site of nitronate monooxygenase”. Bioorg. Chem. 37: 167-172. PMID 19683782.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.