Naftoatna sintaza
Izgled
Naftoatna sintaza | |||||||||
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Naftoatna sintaza hexamer, Mycobacterium tuberculosis | |||||||||
Identifikatori | |||||||||
EC broj | 4.1.3.36 | ||||||||
CAS broj | 61328-42-5 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Naftoatna sintaza (EC 4.1.3.36, 1,4-dihidroksi-2-naftoatna sintaza, dihidroksinaftoatna sintaza, o-sukcinilbenzoil-KoA 1,4-dihidroksi-2-naftoatna-lijaza (ciklizacija), MenB, o-sukcinilbenzoil-KoA dehidrataza (ciklizacija)) je enzim sa sistematskim imenom 4-(2-karboksifenil)-4-oksobutanoil-KoA dehidrataza (ciklizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-(2-karboksifenil)-4-oksobutanoil-KoA 1,4-dihidroksi-2-naftoil-KoA + H2O
Ovaj enzim učestvuje u sintezi 1,4-dihidroksi-2-naftoata.
- ↑ Meganathan, R. and Bentley, R. (1979). „Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes”. J. Bacteriol. 140: 92-98. PMID 500558.
- ↑ Kolkmann, R. and Leistner, E. (1987). „4-(2′-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis”. Z. Naturforsch. C: Sci. 42: 1207-1214. PMID 2966501.
- ↑ Johnson, T.W., Shen, G., Zybailov, B., Kolling, D., Reategui, R., Beauparlant, S., Vassiliev, I.R., Bryant, D.A., Jones, A.D., Golbeck, J.H. and Chitnis, P.R. (2000). „Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. pcc 6803”. J. Biol. Chem. 275: 8523-8530. PMID 10722690.
- ↑ Truglio, J.J., Theis, K., Feng, Y., Gajda, R., Machutta, C., Tonge, P.J. and Kisker, C. (2003). „Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis”. J. Biol. Chem. 278: 42352-42360. PMID 12909628.
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