Ribozildihidronikotinamid dehidrogenaza (hinon)
(Preusmjereno sa stranice NRH:quinone oxidoreductase 2)
| Ribozildihidronikotinamid dehidrogenaza (hinon) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Ribozildihidronikotinamid dehidrogenaza dimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.10.99.2 | ||||||||
| CAS broj | 667919-86-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ribozildihidronikotinamid dehidrogenaza (hinon) (EC 1.10.99.2, NRH:hinon oksidoreduktaza 2, NQO2, NQO2, QR2, hinon reduktaza 2, N-ribozildihidronikotinamid dehidrogenaza (hinon)) je enzim sa sistematskim imenom 1-(beta-D-ribofuranozil)-1,4-dihidronikotinamid:hinon oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1-(beta-D-ribofuranozil)-1,4-dihidronikotinamid + hinon 1-(beta-D-ribofuranozil)nikotinamid + hidrohinon
Ovaj enzim je flavoprotein. Za razliku od EC 1.6.5.2, NAD(P)H dehidrogenaze (hinon), ova hinonska reduktaza ne može da korist NADH ili NADPH. Umesto toga ona koristi N-ribozil- i N-alkildihidronikotinamide. Policiklični aromatični ugljovodonici, kao što su benz[a]antracen, i estrogen 17beta-estradiol i dietilstilbestrol su potentni inhibitori.
Reference[uredi | uredi kod]
- ↑ Liao, S., Dulaney, J.T. and Williams-Ashman, H.G. (1962). „Purification and properties of a flavoprotein catalyzing the oxidation of reduced ribosyl nicotinamide”. J. Biol. Chem. 237: 2981-2987. PMID 14465018.
- ↑ Zhao, Q., Yang, X.L., Holtzclaw, W.D. and Talalay, P. (1997). „Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)”. Proc. Natl. Acad. Sci. USA 94: 1669-1674. PMID 9050836.
- ↑ Wu, K., Knox, R., Sun, X.Z., Joseph, P., Jaiswal, A.K., Zhang, D., Deng, P.S. and Chen, S. (1997). „Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase”. Arch. Biochem. Biophys. 347: 221-228. PMID 9367528.
- ↑ Jaiswal, A.K. (1994). „Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression”. J. Biol. Chem. 269: 14502-14508. PMID 8182056.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.