NAD(P)H oksidaza
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| NAD(P)H oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.6.3.1 | ||||||||
| CAS broj | 77106-92-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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NAD(P)H oksidaza (EC 1.6.3.1, THOX2, ThOX, dualna oksidaza, p138tox, tiroid NADPH oksidaza, tiroidna oksidaza, tiroidna oksidaza 2, NADPH oksidaza) je enzim sa sistematskim imenom NAD(P)H:kiseonik oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- NAD(P)H + H+ + O2 NAD(P)+ +H2O2
Za rad ovog enzima je neophodan FAD, hem i kalcijum.
- ↑ Moreno, J.C., Bikker, H., Kempers, M.J., van Trotsenburg, A.S., Baas, F., de Vijlder, J.J., Vulsma, T. and Ris-Stalpers, C. (2002). „Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347: 95-102. PMID 12110737.
- ↑ De Deken, X., Wang, D., Dumont, J.E. and Miot, F. (2002). „Characterization of ThOX proteins as components of the thyroid H2O2-generating system”. Exp. Cell 273: 187-196. PMID 11822874.
- ↑ De Deken, X., Wang, D., Many, M.C., Costagliola, S., Libert, F., Vassart, G., Dumont, J.E. and Miot, F. (2000). „Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family”. J. Biol. Chem. 275: 23227-23233. PMID 10806195.
- ↑ Dupuy, C., Ohayon, R., Valent, A., Noel-Hudson, M.S., Deme, D. and Virion, A. (1999). „Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs”. J. Biol. Chem. 274: 37265-37269. PMID 10601291.
- ↑ Leseney, A.M., Deme, D., Legue, O., Ohayon, R., Chanson, P., Sales, J.P., Pires de Carvalho, D., Dupuy, C. and Virion, A. (1999). „Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue”. Biochimie 81: 373-380. PMID 10401672.
- ↑ Dupuy, C., Virion, A., Ohayon, R., Kaniewski, J., Deme, D. and Pommier, J. (1991). „Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane”. J. Biol. Chem. 266: 3739-3743. PMID 1995628.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.