N-metilkoklaurin 3'-monooksigenaza
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| N-metilkoklaurin 3'-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.71 | ||||||||
| CAS broj | 202420-37-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-metilkoklaurin 3'-monooksigenaza (EC 1.14.13.71, N-metilkoklaurinska 3'-hidroksilaza) je enzim sa sistematskim imenom (S)-N-metilkoklaurin,NADPH:kiseonik oksidoreduktaza (3'-hidroksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (S)-N-metilkoklaurin + NADPH + H+ + O2 (S)-3'-hidroksi-N-metilkoklaurin + NADP+ + H2O
Ovaj enzim je hem-tiolatni protein (P-450) koji učestvuje u sintezi benzilizohinolinskih alkaloida kod viših biljki.
Reference[uredi | uredi kod]
- ↑ Pauli, H.H. and Kutchan, T.M. (1998). „Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3′-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis”. Plant J. 13: 793-801. PMID 9681018.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.