N-acetilglukozaminil-proteoglikan 4-b-glukuronoziltransferaza
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| N-acetilglukozaminil-proteoglikan 4-b-glukuronoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.225 | ||||||||
| CAS broj | 145539-84-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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N-acetilglukozaminil-proteoglikan 4-b-glukuronoziltransferaza (EC 2.4.1.225, N-acetilglukozaminilproteoglikan beta-1,4-glukuroniltransferaza, heparanska glukuroniltransferaza II) je enzim sa sistematskim imenom UDP-alfa-D-glukuronat:N-acetil-alfa-D-glukozaminil-(1->4)-beta-D-glukuronazil-proteoglikan 4-beta-glukuronaziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-glukuronat + N-acetil-alfa-D-glukozaminil-(1->4)-beta-D-glukuronazil-proteoglikan UDP + beta-D-glukuronazil-(1->4)-N-acetil-alfa-D-glukozaminil-(1->4)-beta-D-glukuronazil-proteoglikan
Ovaj enzim učestvuje u inicijaciji sinteze heparina i heparan sulfata.
Reference[uredi | uredi kod]
- ↑ Senay, C., Lind, T., Muguruma, K., Tone, Y., Kitagawa, H., Sugahara, K., Lidholt, K., Lindahl, U. and Kusche-Gullberg, M. (2000). „The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis”. EMBO Rep. 1: 282-286. PMID 11256613.
- ↑ Lind, T., Tufaro, F., McCormick, C., Lindahl, U. and Lidholt, K. (1998). „The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate”. J. Biol. Chem. 273: 26265-26268. PMID 9756849.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.