Metioninska g-lijaza
| Metioninska g-lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Tetramer metioninske gama-lijaze (Citrobacter freundii) | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.4.1.11 | ||||||||
| CAS broj | 42616-25-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Metioninska g-lijaza (EC 4.4.1.11, L-metioninaza, metioninska lijaza, metioninaza, metioninska detiometilaza, L-metionin gama-lijaza, L-metionin metantiol-lijaza (deaminacija)) je enzim sa sistematskim imenom L-metionin metantiol-lijaza (deaminacija, formira 2-oksobutanoat).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-metionin + H2O metantiol + NH3 + 2-oksobutanoat (sveukupna reakcija)
(1a) L-metionin metantiol + 2-amoniobut-2-enoat (1b) 2-amoniobut-2-enoat + H2O 2-oksobutanoat + NH3 (spontana reakcija)
Ovaj enzim je piridoksal-fosfatni protein.
- ↑ Kreis, W. and Hession, C. (1973). „Isolation and purification of L-methionine-α-deamino-γ-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes”. Cancer Res. 33: 1862-1865. PMID 4720797.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.