Lipoil sintaza

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Lipoil sintaza
Identifikatori
EC broj 2.8.1.8
CAS broj 189398-80-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Lipoil sintaza (EC 2.8.1.8, LS, LipA, lipoat sintaza, protein 6-N-(oktanoil)lizin:sumpor sumportransferaza) je enzim sa sistematskim imenom protein N6-(oktanoil)lizin:sumpor sumportransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

protein N6-(oktanoil)lizin + 2 sumpor + 2 S-adenozil-L-metionin protein N6-(lipoil)lizin + 2 L-metionin + 2 5'-dezoksiadenozin

Ovaj enzim je član familije AdoMet radicala (radicala SAM).

Reference[uredi - уреди | uredi izvor]

  1. Cicchillo, R.M. and Booker, S.J. (2005). "Mechanistic investigations of lipoic acid biosynthesis in Escherichia coli: both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide". J. Am. Chem. Soc. 127: 2860–2861. PMID 15740115. 
  2. Vanden Boom, T.J., Reed, K.E. and Cronan, J.E., Jr. (1991). "Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system". J. Bacteriol. 173: 6411–6420. PMID 1655709. 
  3. Zhao, X., Miller, J.R., Jiang, Y., Marletta, M.A. and Cronan, J.E. (2003). "Assembly of the covalent linkage between lipoic acid and its cognate enzymes". Chem. Biol. 10: 1293–1302. PMID 14700636. 
  4. Cicchillo, R.M., Iwig, D.F., Jones, A.D., Nesbitt, N.M., Baleanu-Gogonea, C., Souder, M.G., Tu, L. and Booker, S.J. (2004). "Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid". Biochemistry 43: 6378–6386. PMID 15157071. 
  5. Jordan, S.W. and Cronan, J.E., Jr. (1997). "A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate dehydrogenase complex in Escherichia coli and mitochondria". J. Biol. Chem. 272: 17903–17906. PMID 9218413. 
  6. Miller, J.R., Busby, R.W., Jordan, S.W., Cheek, J., Henshaw, T.F., Ashley, G.W., Broderick, J.B., Cronan, J.E., Jr. and Marletta, M.A. (2000). "Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein". Biochemistry 39: 15166–15178. PMID 11106496. 
  7. Perham, R.N. (2000). "Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions". Annu. Rev. Biochem. 69: 961–1004. PMID 10966480. 

Literatura[uredi - уреди | uredi izvor]

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