Lipid-A-disaharid sintaza
| Lipid-A-disaharid sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.182 | ||||||||
| CAS broj | 105843-81-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Lipid-A-disaharid sintaza (EC 2.4.1.182, Lipid-A-disaccharide synthase) je enzim sa sistematskim imenom UDP-2,3-bis(3-hidroksitetradekanoil)glukozamin:2,3-bis-(3-hidroksitetradekanoil)-beta-D-glukozaminil-1-fosfat 2,3-bis(3-hidroksitetradekanoil)-glukozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-2,3-bis(3-hidroksitetradekanoil)glukozamin + 2,3-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil 1-fosfat UDP + 2,3-bis(3-hidroksitetradekanoil)-D-glukozaminil-(1->6)-beta-D-2,3-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil 1-fosfat
Ovaj enzim zajedno sa EC 2.3.1.129 (acil-[acil-nosilac-protein]---UDP-N-acetilglukozamin O-aciltransferaza) i EC 2.7.1.130 (tetraacildisaharid 4'-kinaza) učestvuje u biosintezi fosforilisanog glikolipida, Lipid A, u spoljašnjoj membrani Escherichia coli.
- ↑ Crowell, D.N., Reznikoff, W.S. and Raetz, C.R.H. (1987). „Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase”. J. Bacteriol. 169: 5727-5734. PMID 2824445.
- ↑ Ray, B.L., Painter, G. and Raetz, C.R.H. (1984). „The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli”. J. Biol. Chem. 259: 4852-4859. PMID 6370995.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.