Limulusni faktor grušavanja C
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| Limulusni faktor grušavanja C | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.84 | ||||||||
| CAS broj | 115743-27-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Limulusni faktor grušavanja C (EC 3.4.21.84, faktor C, limulusni faktor C) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Selektivno razlaganje -Arg103-Ser- i -Ile124-Ile- veza u limulusnom faktoru zguršavanja B čime se formira faktor overbar B. Razlaganje -Pro-Arg- veza u sintetičkim supstratima
Ovaj enzim je izolovan iz hemocitnih granula vrsta rakova Limulus i Tachypleus.
Reference[uredi | uredi kod]
- ↑ Nakamura, T., Morita, T. and Iwanaga, S. (1986). „Lipopolysaccharide-sensitive serine-protease zymogen (factor C) found in Limulus hemocytes. Isolation and characterization”. Eur. J. Biochem. 154: 511-521. PMID 3512266.
- ↑ Muta, T., Miyata, T., Misumi, Y., Tokunaga, F., Nakamura, T., Toh, Y., Ikehara, Y. and Iwanaga, S. (1991). „Limulus factor C. An endotoxin-sensitive serine protease zymogen with a mosaic structure of complement-like, epidermal growth factor-like, and lectin-like domains”. J. Biol. Chem. 266: 6554-6561. PMID 2007602.
- ↑ Tokunaga, F., Nakajima, H. and Iwanaga, S. (1991). „Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by α-chymotrypsin, not by trypsin”. J. Biochem. (Tokyo) 109: 150-157. PMID 2016264.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.