Leukoantocijanidin reduktaza
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| Leukoantocijanidin reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.1.3 | ||||||||
| CAS broj | 776323-46-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Leukoantocijanidin reduktaza (EC 1.17.1.3, leuocijanidinsk reduktaza) je enzim sa sistematskim imenom (2R,3S)-katehin:NADP+ 4-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2R,3S)-katehin + NADP+ + H2O 2,3-trans-3,4-cis-leuocijanidin + NADPH + H+
Ovaj enzim katalizuje sintezu katehina, katehin-4beta-ola (leuocijanidina) i srodnih flavan-3-ola: afzelehina i galokatehina.
Reference[uredi | uredi kod]
- ↑ Tanner, G.J. and Kristiansen, K.N. (1993). „Synthesis of 3,4-cis-[3H]leucocyanidin and enzymatic reduction to catechin”. Anal. Biochem. 209: 274-277. PMID 8470799.
- ↑ Tanner, G.J., Francki, K.T., Abrahams, S., Watson, J.M., Larkin, P.J. and Ashton, A.R. (2003). „Proanthocyanidin biosynthesis in plants: Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA”. J. Biol. Chem. 278: 31647-31656. PMID 12788945.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.