Laktat-malat transhidrogenaza
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| Laktat-malat transhidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.99.7 | ||||||||
| CAS broj | 9077-15-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Laktat-malat transhidrogenaza (EC 1.1.99.7, malat-laktatna transhidrogenaza) je enzim sa sistematskim imenom (S)-laktat:oksaloacetat oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (S)-laktat + oksaloacetat piruvat + malat
Ovaj enzim katalizuje transfer vodonika sa C3 ili C4 (S)-2-hidroksi kiseline na 2-okso kiseline. On sadrži čvrsto vezani nikotinamidni nukleotid u svom aktivnom centru. Ova prostetička grupa se ne može ukloniti bez denaturacije proteina.
Reference[uredi | uredi kod]
- ↑ Allen, S.H.G. (1966). „The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus”. J. Biol. Chem. 241: 5266-5275. PMID 4289051.
- ↑ Allen, S.H.G. and Patil, J.R. (1972). „Studies on the structure and mechanism of action of the malate-lactate transhydrogenase”. J. Biol. Chem. 247: 909-916. PMID 4333516.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.