Ksilitol oksidaza
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| Ksilitol oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.3.41 | ||||||||
| CAS broj | 177322-52-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ksilitol oksidaza (EC 1.1.3.41, ksilitolna oksidaza, ksilitol:kiseonik oksidoreduktaza, AldO) je enzim sa sistematskim imenom alditol:kiseonik oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim iz Streptomyces vrste IKD472 i iz Streptomyces coelicolor je monomerna oksidaza koja sadrži jedan molekul FAD-a po molekulu proteina. Ksilitol i sorbitol su preferentni supstrati.
Reference[uredi | uredi kod]
- ↑ Yamashita, M., Omura, H., Okamoto, E., Furuya, Y., Yabuuchi, M., Fukahi, K. and Murooka, Y. (2000). „Isolation, characterization, and molecular cloning of a thermostable xylitol oxidase from Streptomyces sp. IKD472”. J. Biosci. Bioeng. 89: 350-360. PMID 16232758.
- ↑ Heuts, D.P., van Hellemond, E.W., Janssen, D.B. and Fraaije, M.W. (2007). „Discovery, characterization, and kinetic analysis of an alditol oxidase from Streptomyces coelicolor”. J. Biol. Chem. 282: 20283-20291. PMID 17517896.
- ↑ Forneris, F., Heuts, D.P., Delvecchio, M., Rovida, S., Fraaije, M.W. and Mattevi, A. (2008). „Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase”. Biochemistry 47: 978-985. PMID 18154360.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.