Klasični-komplementni-put C3/C5 konvertaza
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| Klasični-komplementni-put C3/C5 konvertaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.43 | ||||||||
| CAS broj | 56626-15-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Klasični-komplementni-put C3/C5 konvertaza (EC 3.4.21.43, C3 konvertaza, C overbar 42, C4b,2a, C5 konvertaza, C overbar 423, C4b,2a,3b, C42, C5 konvertaza, C423, C4b,2a,3b, komplement C.hivin.4.hivin2, komplement C3 konvertaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Selektivno razlaganje Arg-Ser veze u komplementnoj komponenti C3 alfa-lanca čime se formiaju C3a i C3b, i Arg- veze u komplementnoj komponenti C5 alfa-lanca čime se formiraju C5a i C5b
Ovaj enzim deluje u kompleksu sa komplementnim fragmentima C4b, C2a i C2b.
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.