Katepsin X

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Katepsin X
Identifikatori
EC broj 3.4.18.1
CAS broj 37217-21-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Katepsin X (EC 3.4.18.1, katepsin B2, karboksipeptidaza cisteinskog tipa, katepsin IV, katepsin Z, kiselina karboksipeptidaza, lizozomalna karboksipeptidaza B) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje C-terminalnih aminokiselinskih ostataks sa širokom specifičšću, sa odsustvom dejstva na C-terminalnom prolinu. Manifestuje slabu endopeptidaznu aktivnost

Katepsin X je lizozomalna cisteinska peptidaza iz familije C1 (papainske familije).

Reference[uredi - уреди | uredi izvor]

  1. Nägler, D.K., Zhang, R., Tam, W., Sulea, T., Purisima, E.O. and Ménard, R. (1999). "Human cathepsin X: A cysteine protease with unique carboxypeptidase activity". Biochemistry 38: 12648–12654. PMID 10504234. 
  2. Nägler, D.K. and Ménard, R. (1998). "Human cathepsin X: A novel cysteine protease of the papain family with a very short proregion and unique insertions". FEBS Lett. 434: 135–139. PMID 9738465. 
  3. Santamaría, I. Velasco, G., Pendás, A.M., Fueyo, A. and López-Otín, C. (1998). "Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location". J. Biol. Chem. 273: 16816–16823. PMID 9642240. 
  4. McDonald, J.K. and Ellis, S. (1975). "On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1". Life Sci. 17: 1269–1276. PMID 577. 
  5. Otto, K. and Riesenkönig, H. (1975). "Improved purification of cathepsin B1 and cathepsin B2". Biochim. Biophys. Acta 379: 462–475. PMID 1122298. 
  6. Ninjoor, V., Taylor, S.L. and Tappel, A.L. (1974). "Purification and characterization of rat liver lysosomal cathepsin B2". Biochim. Biophys. Acta 370: 308–321. PMID 4429705. 

Literatura[uredi - уреди | uredi izvor]

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