Kaspaza-2

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Kaspaza-2
Identifikatori
EC broj 3.4.22.55
CAS broj 182372-14-1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Kaspaza-2 (EC 3.4.22.55, ICH-1, NEDD-2, kaspaza-2L, kaspaza-2S, CASP-2, NEDD2 protein) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Neophodno je prisustvo Asp ostatka u P1 poziciji, pri čemu je Asp316 esencijalan za proteolitičku aktivnost. Preferentno dolazi do razlaganja sekvence Val-Asp-Val-Ala-Asp-

Kaspaze-2 je inicijator kaspaze, kao i kaspaza-8 (EC 3.4.22.61), kaspaza-9 (EC 3.4.22.62) i kaspaza-10 (EC 3.4.22.63).

Reference[uredi - уреди | uredi izvor]

  1. Kumar, S., Kinoshita, M., Noda, M., Copeland, N.G. and Jenkins, N.A. (1994). "Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme". Genes Dev. 8: 1613–1626. PMID 7958843. 
  2. Wang, L., Miura, M., Bergeron, L., Zhu, H. and Yuan, J. (1994). "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death". Cell 78: 739–750. PMID 8087842. 
  3. Li, H., Bergeron, L., Cryns, V., Pasternack, M.S., Zhu, H., Shi, L., Greenberg, A. and Yuan, J. (1997). "Activation of caspase-2 in apoptosis". J. Biol. Chem. 272: 21010–21017. PMID 9261102. 
  4. Mancini, M., Machamer, C.E., Roy, S., Nicholson, D.W., Thornberry, N.A., Casciola-Rosen, L.A. and Rosen, A. (2000). "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis". J. Cell Biol. 149: 603–612. PMID 10791974. 
  5. Zhivotovsky, B. and Orrenius, S. (2005). "Caspase-2 function in response to DNA damage". Biochem. Biophys. Res. Commun. 331: 859–867. PMID 15865942. 
  6. Chang, H.Y. and Yang, X. (2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiol. Mol. Biol. Rev. 64: 821–846. PMID 11104820. 

Literatura[uredi - уреди | uredi izvor]

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