Kalikrein 13
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| Kalikrein 13 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.119 | ||||||||
| CAS broj | 342900-44-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Kalikrein 13 (EC 3.4.21.119, KLK13, kalikrein mK13, mGK-13, mK13, mKLK13, prorenin konvertujući enzim 1, PRECE-1, prorenin-konvertujući enzim, PRECE, proteinaza P) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza mišjeg Ren2 proteina (vrste prorenina prisutnog u submandibularnoj žlezdi) na karboksi strani argininskog ostatka u Lys-Arg- paru u N-terminusu, čime se formira maturisani renin
Ovaj enzim je specifičan za prorenin iz mišje submandibularne žlezde, dok prorenin iz mišjeg bugrega i ljudski prorenin nisu supstrati.
Reference[uredi | uredi kod]
- ↑ Nakayama, K., Kim, W.S., Nakagawa, T., Nagahama, M. and Murakami, K. (1990). „Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis”. J. Biol. Chem. 265: 21027-21031. PMID 2250008.
- ↑ Kim, W.S., Hatsuzawa, K., Ishizuka, Y., Hashiba, K., Murakami, K. and Nakayama, K. (1990). „A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization”. J. Biol. Chem. 265: 5930-5933. PMID 2180937.
- ↑ Kikkawa, Y., Yamanaka, N., Tada, J., Kanamori, N., Tsumura, K. and Hosoi, K. (1998). „Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22)”. Biochim. Biophys. Acta 1382: 55-64. PMID 9507064.
- ↑ Yao, C., Karabasil, M.R., Purwanti, N., Li, X., Akamatsu, T., Kanamori, N. and Hosoi, K. (2006). „Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1β in the submandibular gland of mice”. J. Biol. Chem. 281: 7968-7976. PMID 16423834.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.