Jararhagin

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Jararhagin
Identifikatori
EC broj 3.4.24.73
CAS broj 160477-79-2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Jararhagin (EC 3.4.24.73, HF2-proteinaza, JF1) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza -His10-Leu-, -Ala14-Leu-, -Tyr16-Leu- i -Phe24-Phe- veza u insulinskom B lancu

Ova hemoragička endopeptidaza je prisutna u venumu zmije Bothrops jararaca.

Reference[uredi - уреди | uredi izvor]

  1. Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). "Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca". u: Ohsaka, A., Hayashi, K. and Sawai, Y.. Animal, Plant and Microbial Toxins. New York: Plenum Press. str. 111-121. 
  2. Assakura, M.T., Reichl, A.P. and Mandelbaum, F.R. (1986). "Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)". Toxicon 24: 943–946. PMID 3810664. 
  3. Paine, M.J.I., Desmond, H.P., Theakston, R.D.G. and Crampton, J.M. (1992). "Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family". J. Biol. Chem. 267: 22869–22876. PMID 1385408. 

Literatura[uredi - уреди | uredi izvor]

  • Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). "Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca". u: Ohsaka, A., Hayashi, K. and Sawai, Y.. Animal, Plant and Microbial Toxins. New York: Plenum Press. str. 111-121. 

Vanjske veze[uredi - уреди | uredi izvor]