Izohinolin 1-oksidoreduktaza
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| Izohinolin 1-oksidoreduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.99.16 | ||||||||
| CAS broj | 155948-73-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Izohinolin 1-oksidoreduktaza (EC 1.3.99.16, izohinolinska 1-oksidoreduktaza) je enzim sa sistematskim imenom izohinolin:akceptor 1-oksidoreduktaza (hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- izohinolin + akceptor +H2O izohinolin-1(2H)-on + redukovani akceptor
Ovaj enzim iz Pseudomonas diminuta je specifičan za N-heterociklične supstrate, uključujući izohinolin, izohinolin-5-ol, ftalazin i hinazolin. Elektronski akceptori su 1,2-benzohinon, citohrom c, fericijanid, jodonitrotetrazolijum hlorid, nitroplavo tetrazolijum, Meldola plavo i fenazin metosulfat.
Reference[uredi | uredi kod]
- ↑ Lehmann, M., Tshisuaka, B., Fetzner, S., Roger, P. and Lingens, F. (1994). „Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase”. J. Biol. Chem. 269: 11254-11260. PMID 8157655.
- ↑ Lehmann, M., Tshisuaka, B., Fetzner, S. and Lingens, F. (1995). „Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases”. J. Biol. Chem. 270: 14420-14429. PMID 7782304.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.