Interstinalna kolagenaza
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| Interstinalna kolagenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Monomer kolagenaze (ljudski fibroblast) | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.24.7 | ||||||||
| CAS broj | 2593923 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Interstinalna kolagenaza (EC 3.4.24.7, kolagenaza kičmenjaka, matriks metaloproteinaza 1) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje trostrukog heliksa kolagena na oko tri četvrtine dužine molekula sa N-terminusa, na Gly775-Ile u alfa1(I) lancu. Razlaganje sintetičkih supstrata i alfa-makroglobulina na vezama gde je P1' hidrofoban ostatak
Ovaj enzim je široko rasprostranjen kod kičmenjaka.
Reference[uredi | uredi kod]
- ↑ Goldberg, G.I., Wilhelm, S.M., Kronberger, A., Bauer, E.A., Grant, G.A. and Eisen, A.Z. (1986). „Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein”. J. Biol. Chem. 261: 6600-6605. PMID 3009463.
- ↑ Birkedal-Hansen, H. (1987). „Catabolism and turnover of collagens: collagenases”. Methods Enzymol. 144: 140-171. PMID 3041177.
- ↑ Fields, G.B., Van Wart, H.E. and Birkedal-Hansen, H. (1987). „Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site”. J. Biol. Chem. 262: 6221-6226. PMID 3032960.
- ↑ Sottrup-Jensen, L. and Birkedal-Hansen, H. (1989). „Human fibroblast collagenase-α-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian α-macroglobulins”. J. Biol. Chem. 264: 393-401. PMID 2462561.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.