Horizmatna sintaza

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Horizmatna sintaza
1ZTB.png
Identifikatori
EC broj 4.2.3.5
CAS broj 9077-07-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Horizmatna sintaza (EC 4.2.3.5, 5-O-(1-karboksivinil)-3-fosfošikimat fosfat-lijaza) je enzim sa sistematskim imenom 5-O-(1-karboksivinil)-3-fosfošikimat fosfat-lijaza (formira horizmat).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

5-O-(1-karboksivinil)-3-fosfošikimat \rightleftharpoons horizmat + fosfat

Za dejstvo ovog enzima je neophodan FMN.

Reference[uredi - уреди]

  1. Gaertner, F.H. and Cole, K.W. (1973). "Properties of chorismate synthase in Neurospora crassa". J. Biol. Chem. 248: 4602–4609. PMID 4146266. 
  2. Morell, H., Clark, M.J., Knowles, P.F. and Sprinson, D.B. (1967). "The enzymic synthesis of chorismic and prephenic acids from 3-enolpyruvylshikimic acid 5-phosphate". J. Biol. Chem. 242: 82–90. PMID 4289188. 
  3. Welch, G.R., Cole, K.W. and Gaertner, F.H. (1974). "Chorismate synthase of Neurospora crassa: a flavoprotein". Arch. Biochem. Biophys. 165: 505–518. PMID 4155270. 
  4. Bornemann, S., Lowe, D.J. and Thorneley, R.N. (1996). "The transient kinetics of Escherichia coli chorismate synthase: substrate consumption, product formation, phosphate dissociation, and characterization of a flavin intermediate". Biochemistry 35: 9907–9916. PMID 8703965. 
  5. Bornemann, S., Theoclitou, M.E., Brune, M., Webb, M.R., Thorneley, R.N. and Abell, C. (2000). "A secondary β deuterium kinetic isotope effect in the chorismate synthase reaction". Bioorg. Chem. 28: 191–204. PMID 11034781. 
  6. Osborne, A., Thorneley, R.N., Abell, C. and Bornemann, S. (2000). "Studies with substrate and cofactor analogues provide evidence for a radical mechanism in the chorismate synthase reaction". J. Biol. Chem. 275: 35825–35830. PMID 10956653. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]