Hondroitin-sulfat-ABC eksolijaza
Prijeđi na navigaciju
Prijeđi na pretragu
| Hondroitin-sulfat-ABC eksolijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.2.21 | ||||||||
| CAS broj | 1000607-06-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hondroitin-sulfat-ABC eksolijaza (EC 4.2.2.21, hondroitinaza, hondroitin ABC eliminaza, hondroitinaza ABC, hondroitin ABC lijaza, hondroitin sulfat ABC lijaza, ChS ABC lijaza, hondroitin sulfat ABC eksoeliminaza, hondroitin sulfat ABC eksolijaza, ChS ABC lijaza II) je enzim sa sistematskim imenom hondroitin-sulfat-ABC eksolijaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Eksolitičko odvajanje Delta4-nezasićenih disaharidnih ostataka sa neredukujućih krajeva polimernih hondroitin/dermatan sulfata i njihovih oligosaharidnih fragmenata.
Ovaj enzim degradira mnoštvo glikozaminoglikana hondroitin-sulfat- i dermatan-sulfatnog tipa.
Reference[uredi | uredi kod]
- ↑ Yamagata, T., Saito, H., Habuchi, O. and Suzuki, S. (1968). „Purification and properties of bacterial chondroitinases and chondrosulfatases”. J. Biol. Chem. 243: 1523-1535. PMID 5647268.
- ↑ Saito, H., Yamagata, T. and Suzuki, S. (1968). „Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates”. J. Biol. Chem. 243: 1536-1542. PMID 4231029.
- ↑ Suzuki, S., Saito, H., Yamagata, T., Anno, K., Seno, N., Kawai, Y. and Furuhashi, T. (1968). „Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion”. J. Biol. Chem. 243: 1543-1550. PMID 5647269.
- ↑ Hamai, A., Hashimoto, N., Mochizuki, H., Kato, F., Makiguchi, Y., Horie, K. and Suzuki, S. (1997). „Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides”. J. Biol. Chem. 272: 9123-9130. PMID 9083041.
- ↑ Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). „Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides”. FEBS J. 272: 6276-6286. PMID 16336265.
- ↑ Zhang, Z., Park, Y., Kemp, M.M., Zhao, W., Im, A.R., Shaya, D., Cygler, M., Kim, Y.S. and Linhardt, R.J. (2009). „Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern”. Anal. Biochem. 385: 57-64. PMID 18992215.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.