Holestenon 5a-reduktaza

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Holestenon 5a-reduktaza
EC broj
CAS broj 37255-34-8
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Holestenon 5a-reduktaza (EC, holestenonska 5alfa-reduktaza, testosteronska Delta4-5alfa-reduktaza, steroidna 5alfa-reduktaza, 3-oksosteroidna Delta4-dehidrogenaza, 5alfa-reduktaza, steroidna 5alfa-hidrogenaza, 3-oksosteroidna 5alfa-reduktaza, testosteronska Delta4-hidrogenaza, 4-en-3-oksosteroidna 5alfa-reduktaza, redukovani nikotinamid adenin dinukleotid fosfat:Delta4-3-ketosteroid 5alfa-oksidoreduktaza, 4-en-5alfa-reduktaza, Delta4-3-ketosteroid 5alfa-oksidoreduktaza, holest-4-en-3-on 5alfa-reduktaza, testosteronska 5alfa-reduktaza, 3-okso-5alfa-steroidna 4-dehidrogenaza) je enzim sa sistematskim imenom 3-okso-5alfa-steroid:NADP+ Delta4-oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

3-okso-5alfa-steroid + NADP+ 3-okso-Delta4-steroid + NADPH + H+

Ovaj enzim katalizuje konverziju pojedinih 3-okso-Delta4 steroida u njihovu korespondirajuću 5 alfa formu. Supstrati sisarskog enzima su testosteron, progesteron, i kortikosteron. Supstrati biljnog enzima su brasinosteroidi kao što je kampest-4-en-3-on i (22 alfa)-hidroksi-kampest-4-en-3-on, cf. EC, 3-okso-5alfa-steroid 4-dehidrogenaza (akceptor).

Reference[uredi - уреди | uredi izvor]

  1. Levy, H.R. and Talalay, P. (1959). "Bacterial oxidation of steroids. II. Studies on the enzymatic mechanisms of ring A dehydrogenation". J. Biol. Chem. 234: 2014–2021. PMID 13673006. 
  2. Shefer, S., Hauser, S. and Mosbach, E.H. (1966). "Studies on the biosynthesis of 5α-cholestan-3β-ol. I. Cholestenone 5α-reductase of rat liver". J. Biol. Chem. 241: 946–952. PMID 5907469. 
  3. Cheng, Y.-J. and Karavolas, H.J. (1975). "Properties and subcellular distribution of Δ4-steroid (progesterone) 5α-reductase in rat anterior pituitary". Steroids 26: 57–71. PMID 1166484. 
  4. Sargent, N.S. and Habib, F.K. (1991). "Partial purification of human prostatic 5α-reductase (3-oxo-5α-steroid:NADP+ 4-ene-oxido-reductase; EC in a stable and active form". J. Steroid Biochem. Mol. Biol. 38: 73–77. PMID 1705142. 
  5. Quemener, E., Amet, Y., di Stefano, S., Fournier, G., Floch, H.H. and Abalain, J.H. (1994). "Purification of testosterone 5α-reductase from human prostate by a four-step chromatographic procedure". Steroids 59: 712–718. PMID 7900170. 
  6. Poletti, A., Celotti, F., Rumio, C., Rabuffetti, M. and Martini, L. (1997). "Identification of type 1 5α-reductase in myelin membranes of male and female rat brain". Mol. Cell. Endocrinol. 129: 181–190. PMID 9202401. 
  7. Li, J., Biswas, M.G., Chao, A., Russell, D.W. and Chory, J. (1997). "Conservation of function between mammalian and plant steroid 5α-reductases". Proc. Natl. Acad. Sci. USA 94: 3554–3559. PMID 9108014. 
  8. Rosati, F., Bardazzi, I., De Blasi, P., Simi, L., Scarpi, D., Guarna, A., Serio, M., Racchi, M.L. and Danza, G. (2005). "5α-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes". J. Steroid Biochem. Mol. Biol. 96: 287–299. PMID 15993049. 

Literatura[uredi - уреди | uredi izvor]

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