Histidinol dehidrogenaza
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| Histidinol dehidrogenaza | |||||||||
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| Histidinol dehidrogenaza dimer, E.Coli | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.23 | ||||||||
| CAS broj | 9028-27-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Histidinol dehidrogenaza (EC 1.1.1.23, histidinolna dehidrogenaza, L-histidinol dehidrogenaza) je enzim sa sistematskim imenom L-histidinol:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-histidinol + 2 NAD+ + H2O L-histidin + 2 NADH + 3 H+
Takođe oksiduje L-histidinal. Neurosporni enzim takođe katalizuje reakcije EC 3.5.4.19 (fosforibozil-AMP ciklohidrolaze) i EC 3.6.1.31 (fosforibozil-ATP difosfataze).
Reference[uredi | uredi kod]
- ↑ Adams, E. (1954). „Enzymatic synthesis of histidine from histidinol”. J. Biol. Chem. 209: 829-846. PMID 13192138.
- ↑ Adams, E. (1955). „L-Histidinal, a biosynthetic precursor of histidine”. J. Biol. Chem. 217: 325-344. PMID 13271397.
- ↑ Loper, J.C. (1968). „Histidinol dehydrogenase from Salmonella typhimurium. Crystallization and composition studies”. J. Biol. Chem. 243: 3264-3272. PMID 4872177.
- ↑ Yourno, J. and Ino, I. (1968). „Purification and crystallization of histidinol dehydrogenase from Salmonella typhimurium LT-2”. J. Biol. Chem. 243: 3273-3276. PMID 4872176.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.