Hinolin 2-oksidoreduktaza
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| Hinolin 2-oksidoreduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.99.17 | ||||||||
| CAS broj | 132264-32-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Hinolin 2-oksidoreduktaza (EC 1.3.99.17, hinolinska 2-oksidoreduktaza) je enzim sa sistematskim imenom hinolin:akceptor 2-oksidoreduktaza (hidroksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hinolin + akceptor +H2O hinolin-2(1H)-on + redukovani akceptor
Hinolin-2-ol, hinolin-7-ol, hinolin-8-ol, 3-, 4- i 8-metilhinolini i 8-hlorohinolin su supstrati. Jodonitrotetrazolijum hlorid može da deluje kao elektronski akceptor.
Reference[uredi | uredi kod]
- ↑ Bauder, R., Tshisuaka, B. and Lingens, F. (1990). „Microbial metabolism of quinoline and related compounds. VII. Quinoline oxidoreductase from Pseudomonas putida: a molybdenum-containing enzyme”. Biol. Chem. Hoppe-Seyler 371: 1137-1144. PMID 2090161.
- ↑ Tshisuaka, B., Kappl, R., Huttermann, J. and Lingens, F. (1993). „Quinoline oxidoreductase from Pseudomonas putida 86: an improved purification procedure and electron paramagnetic resonance spectroscopy”. Biochemistry 32: 12928-12934. PMID 8251516.
- ↑ Peschke, B. and Lingens, F. (1991). „Microbial metabolism of quinoline and related compounds. XII. Isolation and characterization of the quinoline oxidoreductase from Rhodococcus sp. B1 compared with the quinoline oxidoreductase from Pseudomonas putida 86”. Biol. Chem. Hoppe-Seyler 372: 1081-1088. PMID 1789933.
- ↑ Schach, S., Tshisuaka, B., Fetzner, S. and Lingens, F. (1995). „Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation”. Eur. J. Biochem. 232: 536-544. PMID 7556204.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.