Glutaril-KoA dehidrogenaza
| Glutaril-KoA dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Glutaril-KoA dehidrogenaza tetramer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.8.6 | ||||||||
| CAS broj | 37255-38-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutaril-KoA dehidrogenaza (EC 1.3.8.6, glutarilna koenzim A dehidrogenaza, glutaril-KoA:(akceptor) 2,3-oksidoreduktaza (dekarboksilacija)) je enzim sa sistematskim imenom glutaril-KoA:elektron-transfer flavoprotein 2,3-oksidoreduktaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- glutaril-KoA + elektron-transfer flavoprotein (E)-but-2-enoil-KoA + CO2 + redukovani elektron-transfer flavoprotein (sveukupna reakcija)
- (1a) glutaril-KoA + elektron-transfer flavoprotein (2E)-4-karboksibut-2-enoil-KoA + redukovani elektron-transfer flavoprotein
- (1b) (2E)-4-karboksibut-2-enoil-KoA (E)-but-2-enoil-KoA + CO2
Ovaj enzim sadrži FAD. Enzim katalizuje oksidaciju glutaril-KoA do glutakonil-KoA.
- ↑ Besrat, A., Polan, C.E. and Henderson, L.M. (1969). „Mammalian metabolism of glutaric acid”. J. Biol. Chem. 244: 1461-1467. PMID 4304226.
- ↑ Hartel, U., Eckel, E., Koch, J., Fuchs, G., Linder, D. and Buckel, W. (1993). „Purification of glutaryl-CoA dehydrogenase from Pseudomonas sp., an enzyme involved in the anaerobic degradation of benzoate”. Arch. Microbiol. 159: 174-181. PMID 8439237.
- ↑ Dwyer, T.M., Zhang, L., Muller, M., Marrugo, F. and Frerman, F. (1999). „The functions of the flavin contact residues, αArg249 and βTyr16, in human electron transfer flavoprotein”. Biochim. Biophys. Acta 1433: 139-152. PMID 10446367.
- ↑ Rao, K.S., Albro, M., Dwyer, T.M. and Frerman, F.E. (2006). „Kinetic mechanism of glutaryl-CoA dehydrogenase”. Biochemistry 45: 15853-15861. PMID 17176108.
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