Glutaril-7-aminocefalosporansko-kiselinska acilaza
| Glutaril-7-aminocefalosporansko-kiselinska acilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.93 | ||||||||
| CAS broj | 56645-46-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutaril-7-aminocefalosporansko-kiselinska acilaza (EC 3.5.1.93, 7beta-(4-karboksibutanamido)cefalosporansko kiselinska acilaza, cefalosporin C acilaza, glutaril-7-ACA acilaza, CA, GCA, GA, cefalosporinska acilaza, glutaril-7-aminocefalosporanska kiselinskaa acilaza, GL-7-ACA acilaza) je enzim sa sistematskim imenom (7R)-7-(4-karboksibutanamido)cefalosporanat amidohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (7R)-7-(4-karboksibutanamido)cefalosporanat + H2O (7R)-7-aminocefalosporanat + glutarat
Ovaj enzim formira 7-aminocefalosporansku kiselinu.
- ↑ Ishii, Y., Saito, Y., Fujimura, T., Sasaki, H., Noguchi, Y., Yamada, H., Niwa, M. and Shimomura, K. (1995). „High-level production, chemical modification and site-directed mutagenesis of a cephalosporin C acylase from Pseudomonas strain N176”. Eur. J. Biochem. 230: 773-778. PMID 7607251.
- ↑ Kinoshita, T., Tada, T., Saito, Y., Ishii, Y., Sato, A. and Murata, M. (2000). „Crystallization and preliminary X-ray analysis of cephalosporin C acylase from Pseudomonas sp. strain N176”. Acta Crystallogr. D Biol. Crystallogr. 56: 458-459. PMID 10739919.
- ↑ Monti, D., Carrea, G., Riva, S., Baldaro, E. and Frare, G. (2000). „Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase”. Biotechnol. Bioeng. 70: 239-244. PMID 10972935.
- ↑ Kwon, T.H., Rhee, S., Lee, Y.S., Park, S.S. and Kim, K.H. (2000). „Crystallization and preliminary X-Ray diffraction analysis of glutaryl-7-aminocephalosporanic acid acylase from Pseudomonas sp. GK16”. J. Struct. Biol. 131: 79-81. PMID 10945972.
- ↑ Kim, Y., Yoon, K.-H., Khang, Y., Turley, S. and Hol, W.G.J. (2000). „The 2.0 Å crystal structure of cephalosporin acylase”. Structure 8: 1059-1068. PMID 11080627.
- ↑ Huang, X., Zeng, R., Ding, X., Mao, X., Ding, Y., Rao, Z., Xie, Y., Jiang, W. and Zhao, G. (2002). „Affinity alkylation of the Trp-B4 residue of the β-subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130”. J. Biol. Chem. 277: 10256-10264. PMID 11782466.
- ↑ Kim, J.K., Yang, I.S., Rhee, S., Dauter, Z., Lee, Y.S., Park, S.S. and Kim, K.H. (2003). „Crystal structures of glutaryl 7-aminocephalosporanic acid acylase: insight into autoproteolytic activation”. Biochemistry 42: 4084-4093. PMID 12680762.
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