Glutaril-7-aminocefalosporansko-kiselinska acilaza

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Glutaril-7-aminocefalosporansko-kiselinska acilaza
Identifikatori
EC broj 3.5.1.93
CAS broj 56645-46-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glutaril-7-aminocefalosporansko-kiselinska acilaza (EC 3.5.1.93, 7beta-(4-karboksibutanamido)cefalosporansko kiselinska acilaza, cefalosporin C acilaza, glutaril-7-ACA acilaza, CA, GCA, GA, cefalosporinska acilaza, glutaril-7-aminocefalosporanska kiselinskaa acilaza, GL-7-ACA acilaza) je enzim sa sistematskim imenom (7R)-7-(4-karboksibutanamido)cefalosporanat amidohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

(7R)-7-(4-karboksibutanamido)cefalosporanat + H2O (7R)-7-aminocefalosporanat + glutarat

Ovaj enzim formira 7-aminocefalosporansku kiselinu.

Reference[uredi - уреди | uredi izvor]

  1. Ishii, Y., Saito, Y., Fujimura, T., Sasaki, H., Noguchi, Y., Yamada, H., Niwa, M. and Shimomura, K. (1995). "High-level production, chemical modification and site-directed mutagenesis of a cephalosporin C acylase from Pseudomonas strain N176". Eur. J. Biochem. 230: 773–778. PMID 7607251. 
  2. Kinoshita, T., Tada, T., Saito, Y., Ishii, Y., Sato, A. and Murata, M. (2000). "Crystallization and preliminary X-ray analysis of cephalosporin C acylase from Pseudomonas sp. strain N176". Acta Crystallogr. D Biol. Crystallogr. 56: 458–459. PMID 10739919. 
  3. Monti, D., Carrea, G., Riva, S., Baldaro, E. and Frare, G. (2000). "Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase". Biotechnol. Bioeng. 70: 239–244. PMID 10972935. 
  4. Kwon, T.H., Rhee, S., Lee, Y.S., Park, S.S. and Kim, K.H. (2000). "Crystallization and preliminary X-Ray diffraction analysis of glutaryl-7-aminocephalosporanic acid acylase from Pseudomonas sp. GK16". J. Struct. Biol. 131: 79–81. PMID 10945972. 
  5. Kim, Y., Yoon, K.-H., Khang, Y., Turley, S. and Hol, W.G.J. (2000). "The 2.0 Å crystal structure of cephalosporin acylase". Structure 8: 1059–1068. PMID 11080627. 
  6. Huang, X., Zeng, R., Ding, X., Mao, X., Ding, Y., Rao, Z., Xie, Y., Jiang, W. and Zhao, G. (2002). "Affinity alkylation of the Trp-B4 residue of the β-subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130". J. Biol. Chem. 277: 10256–10264. PMID 11782466. 
  7. Kim, J.K., Yang, I.S., Rhee, S., Dauter, Z., Lee, Y.S., Park, S.S. and Kim, K.H. (2003). "Crystal structures of glutaryl 7-aminocephalosporanic acid acylase: insight into autoproteolytic activation". Biochemistry 42: 4084–4093. PMID 12680762. 

Literatura[uredi - уреди | uredi izvor]

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