Glutamat dehidrogenaza (NADP+)

Glutamat dehidrogenaza (NADP+)
Identifikatori
EC broj	1.4.1.4
CAS broj	2604121
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Glutamat dehidrogenaza (NADP⁺) (EC 1.4.1.4, glutamatna dehidrogenaza, dehidrogenaza, glutamat (nikotinamid adenin dinukleotid (fosfat)), glutamatno kiselinska dehidrogenaza, L-glutamatna dehidrogenaza, L-glutaminsko kiselinska dehidrogenaza, NAD(P)⁺-glutamatna dehidrogenaza, NAD(P)H-zavisna glutamatna dehidrogenaza, glutamatna dehidrogenaza (NADP⁺)) je enzim sa sistematskim imenom L-glutamat:NADP⁺ oksidoreduktaza (deaminacija).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-glutamat +H₂O + NADP⁺

\rightleftharpoons

2-oksoglutarat + NH₃ + NADPH + H⁺

Reference

↑ Coulton, J.W. and Kapoor, M. (1973). „Purification and some properties of the glutamate dehydrogenase of Salmonella typhimurium”. Can. J. Microbiol. 19: 427-438. PMID 4144743.
↑ Grisolia, S., Quijada, C.L. and Fernandez, M. (1964). „Glutamate dehydrogenase from yeast and from animal tissues”. Biochim. Biophys. Acta 81: 61-70.
↑ Shiio, I. and Ozaki, H. (1970). „Regulation of nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase from Brevibacterium flavum, a glutamate-producing bacterium”. J. Biochem. (Tokyo) 68: 633-647. PMID 4394939.
↑ Smith, E.L., Austen, B.M., Blumenthal, K.M. and Nyc, J.F. (1975). „Glutamate dehydrogenases”. u: Boyer, P.D.. The Enzymes. 11 (3rd izd.). New York: Academic Press. str. 293-367.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH Glutamate+dehydrogenase+(NADP+)

[1] Coulton, J.W. and Kapoor, M. (1973). „Purification and some properties of the glutamate dehydrogenase of Salmonella typhimurium”. Can. J. Microbiol. 19: 427-438. PMID 4144743.

[2] Grisolia, S., Quijada, C.L. and Fernandez, M. (1964). „Glutamate dehydrogenase from yeast and from animal tissues”. Biochim. Biophys. Acta 81: 61-70.

[3] Shiio, I. and Ozaki, H. (1970). „Regulation of nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase from Brevibacterium flavum, a glutamate-producing bacterium”. J. Biochem. (Tokyo) 68: 633-647. PMID 4394939.

[4] Smith, E.L., Austen, B.M., Blumenthal, K.M. and Nyc, J.F. (1975). „Glutamate dehydrogenases”. u: Boyer, P.D.. The Enzymes. 11 (3rd izd.). New York: Academic Press. str. 293-367.

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p r u Proteini: enzimi
Teme	Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6