Germakren-A sintaza
| Germakren-A sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.23 | ||||||||
| CAS broj | 213763-55-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Germakren-A sintaza (EC 4.2.3.23, germakren A sintaza, (+)-germakren A sintaza, (+)-(10R)-germakren A sintaza, GAS, 2-trans,6-trans-farnezil-difosfat difosfat-lijaza (formira germakren-A)) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (+)-(R)-germakren-A).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat (+)-(R)-gemakren A + difosfat
Za dejstvo ovog enzima je neophodan jon Mg2+.
- ↑ Bouwmeester, H.J., Kodde, J., Verstappen, F.W., Altug, I.G., de Kraker, J.W. and Wallaart, T.E. (2002). „Isolation and characterization of two germacrene A synthase cDNA clones from chicory”. Plant Physiol. 129: 134-144. PMID 12011345.
- ↑ Prosser, I., Phillips, A.L., Gittings, S., Lewis, M.J., Hooper, A.M., Pickett, J.A. and Beale, M.H. (2002). „(+)-(10R)-Germacrene A synthase from goldenrod, Solidago canadensis; cDNA isolation, bacterial expression and functional analysis”. Phytochemistry 60: 691-702. PMID 12127586.
- ↑ de Kraker, J.W., Franssen, M.C., de Groot, A., König, W.A. and Bouwmeester, H.J. (1998). „(+)-Germacrene A biosynthesis . The committed step in the biosynthesis of bitter sesquiterpene lactones in chicory”. Plant Physiol. 117: 1381-1392. PMID 9701594.
- ↑ Calvert, M.J., Ashton, P.R. and Allemann, R.K. (2002). „Germacrene A is a product of the aristolochene synthase-mediated conversion of farnesylpyrophosphate to aristolochene”. J. Am. Chem. Soc. 124: 11636-11641. PMID 12296728.
- ↑ Chang, Y.J., Jin, J., Nam, H.Y. and Kim, S.U. (2005). „Point mutation of (+)-germacrene A synthase from Ixeris dentata”. Biotechnol. Lett. 27: 285-288. PMID 15834787.
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