Galaktozilksilozilprotein 3-b-galaktoziltransferaza
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| Galaktozilksilozilprotein 3-b-galaktoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.134 | ||||||||
| CAS broj | 56626-19-8&title= 56626-21-2, 56626-19-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Galaktozilksilozilprotein 3-b-galaktoziltransferaza (EC 2.4.1.134, galaktoziltransferaza II, uridin difosfogalaktoza-galaktozilksilozna galaktoziltransferaza, UDP-galaktoza:4-beta-D-galaktozil-O-beta-D-ksilozilprotein 3-beta-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:4-beta-D-galaktozil-O-beta-D-ksilosilprotein 3-beta-D-galaktoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-galaktoza + 4-beta-D-galaktozil-O-beta-D-ksilozil-[protein] UDP + 3-beta-D-galaktozil-4-beta-D-galaktozil-O-beta-D-ksilozil-[protein]
Ovaj enzim učestvuje u biosintezi veznog regiona glikozaminoglikanskih lanaca tokom proteoglikanske biosinteze (hondroitin, dermatan i heparan sulfati). Za njegov rad je neophodan Mn2+.
Reference[uredi | uredi kod]
- ↑ Robinson, J.A. and Robinson, H.C. (1985). „Initiation of chondroitin sulphate synthesis by β-D-galactosides. Substrates for galactosyltransferase II”. Biochem. J. 227: 805-814. PMID 3924029.
- ↑ Schwartz, N.B. and Roden, L. (1975). „Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltransferase”. J. Biol. Chem. 250: 5200-5207. PMID 1150655.
- ↑ Bai, X., Zhou, D., Brown, J.R., Crawford, B.E., Hennet, T. and Esko, J.D. (2001). „Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the β1,3-galactosyltransferase family (β3GalT6)”. J. Biol. Chem. 276: 48189-48195. PMID 11551958.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.