Galaktozilgalaktozilksilozilprotein 3-b-glukuronoziltransferaza
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| Galaktozilgalaktozilksilozilprotein 3-b-glukuronoziltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.4.1.135 | ||||||||
| CAS broj | 227184-75-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Galaktozilgalaktozilksilozilprotein 3-b-glukuronoziltransferaza (EC 2.4.1.135, glukuronaziltransferaza I, uridin difosfat glukuronska kiselina:akceptor glukuronaziltransferaza, UDP-glukuronat:3-beta-D-galaktozil-4-beta-D-galaktozil-O-beta-D-ksilozil-protein D-glukuronaziltransferaza) je enzim sa sistematskim imenom UDP-glukuronat:3-beta-D-galaktozil-4-beta-D-galaktozil-O-beta-D-ksilosilprotein D-glukuronaziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-glukuronat + 3-beta-D-galaktozil-4-beta-D-galaktozil-O-beta-D-ksilozilprotein UDP + 3-beta-D-glukuronazil-3-beta-D-galaktozil-4-beta-D-galaktozil-O-beta-D-ksilozilprotein
Ovaj enzim učestvuje u biosintezi veznog regiona glikozaminoglikanskih lanaca tokom proteoglikanske biosinteze (hondroitin, dermatan i heparan sulfati). Za njegov rad je neophodan Mn2+.
Reference[uredi | uredi kod]
- ↑ Helting, J. and Roden, L. (1969). „Biosynthesis of chondroitin sulfate. II. Glucuronosyl transfer in the formation of the carbohydrate-protein linkage region”. J. Biol. Chem. 244: 2799-2805. PMID 5770003.
- ↑ Helting, T. (1972). „Biosynthesis of heparin. Solubilization and partial purification of uridine diphosphate glucuronic acid: acceptor glucuronosyltransferase from mouse mastocytoma”. J. Biol. Chem. 247: 4327-4332. PMID 4260846.
- ↑ Kitagawa, H., Tone, Y., Tamura, J., Neumann, K.W., Ogawa, T., Oka, S., Kawasaki, T. and Sugahara, K. (1998). „Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans”. J. Biol. Chem. 273: 6615-6618. PMID 9506957.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.