GTP ciklohidrolaza I
| GTP ciklohidrolaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.5.4.16 | ||||||||
| CAS broj | 37289-19-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
GTP ciklohidrolaza I (EC 3.5.4.16, GTP ciklohidrolaza, guanozin trifosfatna ciklohidrolaza, guanozin trifosfat 8-deformilaza, dihidroneopterin trifosfatna sintaza, GTP 8-formilhidrolaza) je enzim sa sistematskim imenom GTP 7,8-8,9-dihidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GTP + H2O format + 7,8-dihidroneopterin 3'-trifosfat
Rreakcija se sastoji od hidrolize dve C-N veze i izomerizacije pentozne jedinice. Reciklizacija može da bude neenzimatska.
- ↑ Burg, A.W. and Brown, G.M. (1968). „The biosynthesis of folic acid. 8. Purification and properties of the enzyme that catalyzes the production of formate from carbon atom 8 of guanosine triphosphate”. J. Biol. Chem. 243: 2349-2358. PMID 4296838.
- ↑ Wolf, W.A. and Brown, G.M. (1969). „The biosynthesis of folic acid. X. Evidence for an Amadori rearrangement in the enzymatic formation of dihydroneopterin triphosphate from GTP”. Biochim. Biophys. Acta 192: 468-478. PMID 4904679.
- ↑ Supangat, S., Choi, Y.K., Park, Y.S., Son, D., Han, C.D. and Lee, K.H. (2005). „Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 202-204. PMID 16510994.
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