GNA13

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Guanin nukleotid-vezujući protein (G protein), alfa 13

PDB prikaz baziran na 1zcb.
Dostupne strukture
1zcb
Identifikatori
Simboli GNA13; G13; MGC46138
Vanjski ID OMIM604406 MGI95768 HomoloGene55976 GeneCards: GNA13 Gene
Pregled RNK izražavanja
PBB GE GNA13 206917 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 10672 14674
Ensembl ENSG00000120063 ENSMUSG00000020611
UniProt Q14344 Q3UE40
RefSeq (mRNA) NM_006572 NM_010303
RefSeq (protein) NP_006563 NP_034433
Lokacija (UCSC) Chr 17:
60.44 - 60.48 Mb
Chr 11:
109.18 - 109.21 Mb
PubMed pretraga [1] [2]

GNA13, Guanin nukleotid-vezujući protein alfa 13 je protein koji je kod ljudi kodiran GNA13 genom.[1][2]

Interactions[uredi - уреди | uredi izvor]

Za GNA12 je bilo pokazano da interaguje sa ARHGEF1,[3][4] AKAP3,[5] RIC8A,[6] Radixin[7] i ARHGEF12.[8][9]

Reference[uredi - уреди | uredi izvor]

  1. Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (Jul 1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Mol Cell Biochem 144 (1): 45–51. PMID 7791744. doi:10.1007/BF00926739.  Check date values in: |date= (help)
  2. "Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10672. 
  3. Bhattacharyya, Raja; Wedegaertner Philip B (April 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. (Netherlands) 540 (1-3): 211–6. ISSN 0014-5793. PMID 12681510. doi:10.1016/S0014-5793(03)00267-9. 
  4. Hart, M J; Jiang X, Kozasa T, Roscoe W, Singer W D, Gilman A G, Sternweis P C, Bollag G (June 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science (UNITED STATES) 280 (5372): 2112–4. ISSN 0036-8075. PMID 9641916. doi:10.1126/science.280.5372.2112. 
  5. Niu, J; Vaiskunaite R, Suzuki N, Kozasa T, Carr D W, Dulin N, Voyno-Yasenetskaya T A (October 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Curr. Biol. (England) 11 (21): 1686–90. ISSN 0960-9822. PMID 11696326. doi:10.1016/S0960-9822(01)00530-9. 
  6. Tall, Gregory G; Krumins Andrejs M, Gilman Alfred G (March 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. (United States) 278 (10): 8356–62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200. 
  7. Vaiskunaite, R; Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya T A (August 2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. (UNITED STATES) 275 (34): 26206–12. ISSN 0021-9258. PMID 10816569. doi:10.1074/jbc.M001863200. 
  8. Fukuhara, S; Chikumi H, Gutkind J S (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. (NETHERLANDS) 485 (2-3): 183–8. ISSN 0014-5793. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9. 
  9. Suzuki, Nobuchika; Nakamura Susumu, Mano Hiroyuki, Kozasa Tohru (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. ISSN 0027-8424. PMC 141065. PMID 12515866. doi:10.1073/pnas.0234057100. 

Literatura[uredi - уреди | uredi izvor]

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