GNA12

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Guanin nukleotid-vezujući protein (G protein), alfa 12

PDB prikaz baziran na 1zca.
Dostupne strukture
1zca
Identifikatori
SimboliGNA12; RMP; MGC104623; MGC99644; NNX3; gep
Vanjski IDOMIM604394 MGI95767 HomoloGene22398 GeneCards: GNA12 Gene
Pregled RNK izražavanja
PBB GE GNA12 221737 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez276814673
EnsemblENSG00000146535ENSMUSG00000000149
UniProtQ03113Q2NKI3
RefSeq (mRNA)NM_007353XM_001001104
RefSeq (protein)NP_031379XP_001001104
Lokacija (UCSC)Chr 7:
2.73 - 2.85 Mb
Chr 5:
141.01 - 141.08 Mb
PubMed pretraga[1][2]

GNA12, Guanin nukleotid-vezujući protein alfa 12, je protein koji je kod ljudi kodiran GNA12 genom.[1][2][3]

Interakcije[uredi - уреди | uredi izvor]

Za GNA12 je bilo pokazano da interaguje sa ARHGEF1, PPP5C,[4] ARHGEF12,[5][6] citosolinim proteinom toplotnog udara 90 kDa alfa, članom A1[7] i TEC.[6]

Reference[uredi - уреди | uredi izvor]

  1. Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Stuart A. Aaronson (Feb 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Mol Cell Biol 13 (2): 762–8. PMC 358958. PMID 8423800.  Check date values in: |date= (help)
  2. Kumar RN, Shore SK, Dhanasekaran N (Feb 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene 25 (6): 899–906. PMID 16247467. doi:10.1038/sj.onc.1209132.  Check date values in: |date= (help)
  3. "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2768. 
  4. Yamaguchi, Yoshiaki; Katoh Hironori, Mori Kazutoshi, Negishi Manabu (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Curr. Biol. (England) 12 (15): 1353–8. ISSN 0960-9822. PMID 12176367. doi:10.1016/S0960-9822(02)01034-5. 
  5. Fukuhara, S; Chikumi H, Gutkind J S (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. (NETHERLANDS) 485 (2-3): 183–8. ISSN 0014-5793. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9. 
  6. 6,0 6,1 Suzuki, Nobuchika; Nakamura Susumu, Mano Hiroyuki, Kozasa Tohru (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. ISSN 0027-8424. PMC 141065. PMID 12515866. doi:10.1073/pnas.0234057100. 
  7. Vaiskunaite, R; Kozasa T, Voyno-Yasenetskaya T A (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". J. Biol. Chem. (United States) 276 (49): 46088–93. ISSN 0021-9258. PMID 11598136. doi:10.1074/jbc.M108711200. 

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