Format dehidrogenaza-N
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| Format dehidrogenaza-N | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.5.6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Format dehidrogenaza-N (EC 1.1.5.6, Fdh-N, FdnGHI, format dehidrogenaza indukovana nitratom, formatna dehidrogenaza N, FDH-N, nitratom inducibilna Fdn, nitratom inducibilna formatna dehidrogenaza) je enzim sa sistematskim imenom format:hinon oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim sadrži molibdopterin-guaninske dinukleotide, pet [4Fe-4S] klastera i dve hem b grupe. Format dehidrogenaza-N oksiduje format u periplazmi, prenoseći electrone putem menahinona u citoplazmičnoj membrani do disimilatorne nitratne reduktaze (EC 1.7.5.1), koja prenosi electrone do nitrata u citoplazmi.
Reference[uredi | uredi kod]
- ↑ Enoch, H.G. and Lester, R.L. (1975). „The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli”. J. Biol. Chem. 250: 6693-6705. PMID 1099093.
- ↑ Jormakka, M., Tornroth, S., Byrne, B. and Iwata, S. (2002). „Molecular basis of proton motive force generation: structure of formate dehydrogenase-N”. Science 295: 1863-1868. PMID 11884747.
- ↑ Jormakka, M., Tornroth, S., Abramson, J., Byrne, B. and Iwata, S. (2002). „Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli”. Acta Crystallogr. D Biol. Crystallogr. 58: 160-162. PMID 11752799.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.