Fibrolaza

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Fibrolaza
Identifikatori
EC broj 3.4.24.72
CAS broj 116036-70-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Fibrolaza (EC 3.4.24.72, fibrinolitička proteinaza, Agkistrodon contortrix contortrix metaloproteinaza, Agkistrodon contortrix contortrix venomna metaloproteinaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza -Ala14-Leu- u insulinskom B lancu i -Lys413-Leu- u Aalfa-lancu fibrinogena

Ovaj enzim je prisutan u venumu zmije Agkistrodon contortix contortix.

Reference[uredi - уреди | uredi izvor]

  1. Retzios, A.D. and Markland, F.S., Jr. (1988). "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems". Thromb. Res. 52: 541–552. PMID 3232124. 
  2. Guan, A.L., Retzios, A.D., Henderson, G.N. and Markland, F.S., Jr. (1991). "Purification and characterization of a fibrinolytic enzyme from venom of southern copperhead snake (Agkistrodon contortrix contortrix)". Arch. Biochem. Biophys. 289: 197–207. PMID 1898066. 
  3. Randolph, A., Chamberlain, S.H., Chu, H.L.C., Retzios, A.D., Markland, F.S. (1992). "Jr. and Masiarz, F.R. Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix venom". Protein Sci. 1: 590–600. PMID 1304358. 
  4. Loayza, S.L., Trikha, M., Markland, F.S., Riquelme, P. and Kuo, J. (1994). "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities". J. Chromatogr. B Biomed. Appl. 662: 227–243. PMID 7719479. 
  5. Retzios, A.D. and Markland, F.S. (1994). "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basilicus basilicus: cleavage site specificity towards the α-chain of fibrin". Thromb. Res. 74: 355–367. PMID 8085237. 

Literatura[uredi - уреди | uredi izvor]

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