Fenilalanin dehidrogenaza
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| Fenilalanin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.1.20 | ||||||||
| CAS broj | 69403-12-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fenilalanin dehidrogenaza (EC 1.4.1.20, L-fenilalaninska dehidrogenaza, PHD) je enzim sa sistematskim imenom L-fenilalanin:NAD+ oksidoreduktaza (deaminacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-fenilalanin +H2O + NAD+ fenilpiruvat + NH3 + NADH + H+
Enzimi iz Bacillus badius i Sporosarcina ureae su visoko specifični za L-fenilalanin; dok enzim iz Bacillus sphaericus takođe deluje na L-tirozin.
Reference[uredi | uredi kod]
- ↑ Asano, Y., Nakazawa, A. and Endo, K. (1987). „Novel phenylalanine dehydrogenases from Sporosarcina ureae and Bacillus sphaericus. Purification and characterization”. J. Biol. Chem. 262: 10346-10354. PMID 3112142.
- ↑ Asano, Y., Nakazawa, A., Endo, K., Hibino, Y., Ohmori, M., Numao, N. and Kondo, K. (1987). „Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning”. Eur. J. Biochem. 168: 153-159. PMID 3311741.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.