Fenilalanin 2-monooksigenaza
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| Fenilalanin 2-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.12.9 | ||||||||
| CAS broj | 190396-37-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fenilalanin 2-monooksigenaza (EC 1.13.12.9, L-fenilalanin oksidaza (deaminacija i dekarboksilacija), fenilalanin (deaminacija, dekarboksilacija)oksidaza) je enzim sa sistematskim imenom L-fenilalanin:kiseonik 2-oksidoreduktaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-fenilalanin + O2 2-fenilacetamid + CO2 +H2O
Gornja reakcija je glavna katalizovana reakcija (80%). Osim nje se odvija i reakcija:
- L-fenilalanin + O2 + H2O = 3-fenilpiruvinska kiselina + amonijak + H2O2 .
Reference[uredi | uredi kod]
- ↑ Koyama, H. (1982). „Purification and characterization of a novel L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501”. J. Biochem. (Tokyo) 92: 1235-1240. PMID 7174643.
- ↑ Koyama, H. (1984). „Oxidation and oxygenation of L-amino acids catalyzed by a L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501”. J. Biochem. (Tokyo) 96: 421-427. PMID 6501250.
- ↑ Koyama, H. (1984). „A simple and rapid enzymatic determination of L-phenylalanine with a novel L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501”. Clin. Chim. Acta 1361: 131-136. PMID 6692570.
- ↑ Koyama, H. and Suzuki, H. (1986). „Spectral and kinetic studies on Pseudomonas L-phenylalanine oxidase (deaminating and decarboxylating)”. J. Biochem. (Tokyo) 100: 859-866. PMID 3818566.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.