Koštani morfogenetički protein 7
(Preusmjereno sa stranice Eptotermin alfa)
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| Koštani morfogenetički protein 7 | |||||||||||
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 Kristalna struktura koštano morfogenetičkog proteina 7 (BMP-7) u kompleksu sa izlučenim antagonistom Noginom. PDB prikaz baziran na 1m4u. | |||||||||||
| Dostupne strukture | |||||||||||
| 1BMP, 1LX5, 1LXI, 1M4U | |||||||||||
| Identifikatori | |||||||||||
| Simboli | BMP7; OP-1 | ||||||||||
| Vanjski ID | OMIM: 112267 MGI: 103302 HomoloGene: 20410 GeneCards: BMP7 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 655 | 12162 | |||||||||
| Ensembl | ENSG00000101144 | ENSMUSG00000008999 | |||||||||
| UniProt | P18075 | P23359 | |||||||||
| Ref. Sekv. (iRNK) | NM_001719 | NM_007557 | |||||||||
| Ref. Sekv. (protein) | NP_001710 | NP_031583 | |||||||||
| Lokacija (UCSC) | Chr 20: 55.74 - 55.84 Mb | Chr 2: 172.87 - 172.94 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Koštani morfogenetički protein 7 ili BMP7 (takođe poznat kao osteogenski protein-1 ili OP-1) je protein koji je kod ljudi kodiran BMP7 genom.[1]
Funkcija[uredi | uredi kod]
Protein kodiran ovim genom je član TGF-β superfamilije. Poput drugih članova familije koštano morfogenetičkih proteina, on ima značajnu ulogu u transformaciji mesenhimalnih ćelija u kost i hrskavicu. Njega inhibira nogin i slični protein, hordin. Smatra se da BMP7 doprinosi koštanoh homeostazi. On je izražen u mozgu, bubrezima i bešiki.[2]
BMP7 indukuje fosforilaciju SMAD1 i SMAD5, koji zatim indukuju transkripciju brojnih osteogenih gena.[3] Pokazano je da je BMP7 tretman dovoljan da se indukuju svi genetički markeri osteoblastne diferencijacije u mnoštvu ćelijskih tipova.[2]
Reference[uredi | uredi kod]
- ↑ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (November 1992). „A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7”. Genomics 14 (3): 759–62. DOI:10.1016/S0888-7543(05)80181-8. PMID 1427904.
- ↑ 2,0 2,1 Chen D, Zhao M, Mundy GR (December 2004). „Bone morphogenetic proteins”. Growth Factors 22 (4): 233–41. DOI:10.1080/08977190412331279890. PMID 15621726.
- ↑ Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (August 2001). „Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads”. EMBO J. 20 (15): 4132–42. DOI:10.1093/emboj/20.15.4132. PMC 149146. PMID 11483516.
Literatura[uredi | uredi kod]
- Xiao HQ, Shi W, Zhang Y, Liang YZ (2009). „[Effect of bone morphogenic protein 7 on nephrin expression and distribution in diabetic rat kidneys]”. Nan Fang Yi Ke Da Xue Xue Bao 29 (4): 671–5. PMID 19403392.
- Murray LA, Hackett TL, Warner SM, et al. (2008). Eickelberg, Oliver. ur. „BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.”. PLoS ONE 3 (12): e4039. DOI:10.1371/journal.pone.0004039. PMC 2603595. PMID 19112509.
- Freedman BI, Bowden DW, Ziegler JT, et al. (2009). „Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study”. J. Bone Miner. Res. 24 (10): 1719–27. DOI:10.1359/jbmr.090501. PMC 2743282. PMID 19453255.
- Garriock HA, Kraft JB, Shyn SI, et al. (2010). „A genomewide association study of citalopram response in major depressive disorder”. Biol. Psychiatry 67 (2): 133–8. DOI:10.1016/j.biopsych.2009.08.029. PMC 2794921. PMID 19846067.
- Reddi AH (2000). „Bone morphogenetic proteins and skeletal development: the kidney-bone connection”. Pediatr. Nephrol. 14 (7): 598–601. DOI:10.1007/s004670000364. PMID 10912525.
- Gautschi OP, Cadosch D, Zellweger R, et al. (2009). „Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7”. J Musculoskelet Neuronal Interact 9 (1): 53–60. PMID 19240369.
- Alarmo EL, Pärssinen J, Ketolainen JM, et al. (2009). „BMP7 influences proliferation, migration, and invasion of breast cancer cells”. Cancer Lett. 275 (1): 35–43. DOI:10.1016/j.canlet.2008.09.028. PMID 18980801.
- Elshaier AM, Hakimiyan AA, Rappoport L, et al. (2009). „Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes”. Arthritis Rheum. 60 (1): 143–54. DOI:10.1002/art.24151. PMC 2626196. PMID 19116903.
- Yerges LM, Klei L, Cauley JA, et al. (2009). „High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men”. J. Bone Miner. Res. 24 (12): 2039–49. DOI:10.1359/jbmr.090524. PMC 2791518. PMID 19453261.
- Dudas PL, Argentieri RL, Farrell FX (2009). „BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells”. Nephrol. Dial. Transplant. 24 (5): 1406–16. DOI:10.1093/ndt/gfn662. PMID 19056781.
- Honsawek S, Chayanupatkul M, Tanavalee A, et al. (2009). „Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study”. Int Orthop 33 (4): 1171–5. DOI:10.1007/s00264-009-0751-z. PMC 2898966. PMID 19301001.
- Sengle G, Ono RN, Lyons KM, et al. (2008). „A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7”. J. Mol. Biol. 381 (4): 1025–39. DOI:10.1016/j.jmb.2008.06.074. PMC 2705212. PMID 18621057.
- Mitu G, Hirschberg R (2008). „Bone morphogenetic protein-7 (BMP7) in chronic kidney disease”. Front. Biosci. 13: 4726–39. PMID 18508541.
- Brown A, Stock G, Patel AA, et al. (2006). „Osteogenic protein-1 : a review of its utility in spinal applications”. BioDrugs 20 (4): 243–51. DOI:10.2165/00063030-200620040-00005. PMID 16831023.
- Fajardo M, Liu CJ, Egol K (2009). „Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study”. Clin. Orthop. Relat. Res. 467 (12): 3071–8. DOI:10.1007/s11999-009-0981-9. PMC 2772945. PMID 19597895.
- Giannoudis PV, Kanakaris NK, Dimitriou R, et al. (2009). „The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions”. Clin. Orthop. Relat. Res. 467 (12): 3239–48. DOI:10.1007/s11999-009-0846-2. PMC 2772926. PMID 19396502.
- Kalluri R, Neilson EG (2003). „Epithelial-mesenchymal transition and its implications for fibrosis”. J. Clin. Invest. 112 (12): 1776–84. DOI:10.1172/JCI20530. PMC 297008. PMID 14679171.
- Zhu L, Chuanchang D, Wei L, et al. (2010). „Enhanced healing of goat femur-defect using BMP7 gene-modified BMSCs and load-bearing tissue-engineered bone”. J. Orthop. Res. 28 (3): 412–8. DOI:10.1002/jor.20973. PMID 19725097.
- Vieira AR, McHenry TG, Daack-Hirsch S, et al. (2008). „Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts”. Genet. Med. 10 (9): 668–74. DOI:10.1097/GIM.0b013e3181833793. PMC 2734954. PMID 18978678.
- Kron K, Pethe V, Briollais L, et al. (2009). Blagosklonny, Mikhail V.. ur. „Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays”. PLoS ONE 4 (3): e4830. DOI:10.1371/journal.pone.0004830. PMC 2653233. PMID 19283074.
Vanjske veze[uredi | uredi kod]
- MeSH bone morphogenetic protein 7
- BMP7 as Molecule of the Year 2011 Arhivirano 2016-03-04 na Wayback Machine-u
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